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EZH2, HISTONE-LYSINE N-METHYLTRANSFERASE
Descriptors Found:
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DeCS
Descriptor
English
:
Enhancer of Zeste Homolog 2 Protein
Descriptor
Spanish
:
homólogo 2 del potenciador de zeste
Descriptor
Portuguese
:
Proteína Potenciadora do Homólogo 2 de Zeste
Synonyms
English
:
EZH2, Histone-Lysine N-Methyltransferase
Enhancer of Zeste Homolog 2
Histone Lysine N Methyltransferase EZH2
Histone-Lysine N-Methyltransferase EZH2
Lysine N Methyltransferase 6
Lysine N-Methyltransferase-6
Tree Number:
D05.500.781.750.250
D08.811.913.555.500.800.200.500.500.500
D12.776.660.235.600.200.250
D12.776.664.235.800.200.250
D12.776.930.780.890.200.250
Definition
English
:
A
histone-lysine N-methyltransferase
and catalytic subunit of
Polycomb Repressive Complex 2
. It methylates
LYSINE
9 (H3K9me) and
LYSINE
27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone
proteins
such as
GATA4 TRANSCRIPTION FACTOR
and the nuclear receptor RORA. It regulates
CIRCADIAN CLOCKS
via histone
methylation
of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of
EMBRYONIC STEM CELLS.
History Note
English
:
2017 (2005)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56434
Unique Identifier:
D000071221
Occurrence in VHL
:
Similar:
DeCS